After suffering an overtime loss to the Chiefs in Super Bowl 58, the 49ers will begin their season on Monday Night Football against the Jets. It's the final matchup of Week 1, and with Aaron Rodgers returning from a torn Achilles, it could even be a preview of Super Bowl 59 with both teams possessing strong rosters. San Francisco is a 4.5-point home favorite in the latest Week 1 NFL odds, but went just 9-11 against the spread last season.

Meanwhile, the Lions were runners-up in the NFC and will open their season on Sunday Night Football against the Los Angeles Rams in a rematch of an NFC wild card battle last season. Detroit is a 3.5-point favorite in the NFL spreads and NFL betting lines. Who should you back in those games as you make your Week 1 NFL score predictions and which Week 1 NFL lines did oddsmakers get wrong altogether? Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.

Top Week 1 NFL AI picks

After analyzing every game in Week 1, the AI PickBot says the Broncos cover as six-point underdogs against the Seahawks in a game that has earned an A-rated pick. After ranking last in the NFL in points per game in 2022, Sean Payton made a clear difference in 2023 and Denver wound up finishing 19th in scoring in his first season. Meanwhile, the defense went from seventh in yards allowed to 29th but was able to tread water by forcing turnovers and standing tall on third downs.

The Broncos ranked 12th in the NFL with 26 takeaways and were second in the league in opponents' third-down conversion rate (33.2%). Meanwhile, the Seattle defense struggled to get off the field on third downs last season, allowing opponents to convert on 46.2% of those opportunities (30th in the NFL). That's a big reason why the AI PickBot see this contest being much closer than the oddsmakers, predicting that the Seahawks only win 21.86-20.34 on average. See its other Week 1 football predictions and football picks at SportsLine.

How to make Week 1 NFL picks

In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot's analysis before making any Week 1 NFL bets. You can only see it at SportsLine.

Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that